The new building was a Golden Jubilee project, created to mark Saskatchewan's 50th anniversary in confederation. In 1953, the construction of the museum building began. After years of relocating, this would be the Museum's first permanent home. The original cost of the building was expected to be $500,000; however, the end cost totaled $1.5 million (approximately $11.2 million today).

Governor-General Vincent Massey opened the Museum's new home on May 16, 1955. With 20,000 square feet (1,858 square metres) of gallery space, plus laboratories, work areas, office and storage space, the Museum no longer had to worry about overcrowding and the threat of being forced to relocate. The new extensive amount of gallery space provided room for large scale dioramas to depict many areas of the province.

pmgm architecture ltd. has been involved in many renovation projects with the Royal Saskatchewan Museum;
1995 - Life Science Gallery, Regina
1997 - Theatre Renovations, Regina
1998 - Phase II - Life Sciences Gallery, Regina
1998 - Foyer Renovations, Regina
2001 - Interior Upgrading, Regina
2007 - Assessment / Feasibility Study 2007, Regina